表觀遺傳研究

國內學者使用2022世界杯竞猜app下载表觀遺傳服務發表的SCI成果

DNA hydroxymethylation reprogramming of β-oxidation genes mediates early-life arsenic-evoked hepatic lipid accumulation in adult mice . Journal of Hazardous Materials . 2022

Circular RNA ACTN4 promotes intrahepatic cholangiocarcinoma progression by recruiting YBX1 to initiate FZD7 transcription. Journal of Hepatology . 2021

Oncogenic role of SOX9-DHCR24-cholesterol biosynthesis axis in IGH-BCL2 positive diffuse large B-cell lymphomas. Blood . 2021

Ten-eleven translocation 1 mediated-DNA hydroxymethylation is required for myelination and remyelination in the mouse brain. Nature communications . 2021

DNA methylation and hydroxymethylation associated with gene expression regulatory network during 3-methylcholanthrene induced lung cell malignant transformation. Science of The Total Environment . 2021

Paternal exposure to microcystin-LR triggers developmental neurotoxicity in zebrafish offspring via an epigenetic mechanism involving MAPK pathway. Science of The Total Environment . 2021

Calcitonin gene‐related peptide induces the histone H3 lysine 9 acetylation in astrocytes associated with neuroinflammation in rats with neuropathic pain. CNS Neuroscience & Therapeutics . 2021

Calcitonin gene-related peptide regulates spinal microglial activation through the histone H3 lysine 27 trimethylation via enhancer of zeste homolog-2 in rats with neuropathic pain. Journal of neuroinflammation . 2021

BRD4 inhibition alleviates mechanical stress-induced TMJ OA-like pathological changes and attenuates TREM1-mediated inflammatory response. Clinical Epigenetics . 2021

Histone demethylase KDM6A promotes somatic cell reprogramming by epigenetically regulating the PTEN and IL‐6 signal pathways . STEM CELLS . 2020

Multi-generational obesogenic effects of sulfomethoxazole on Caenorhabditis elegans through epigenetic regulation . Journal of Hazardous Materials . 2019

Interplay of miR-137 and EZH2 contributes to the genome-wide redistribution of H3K27me3 underlying the Pb-induced memory impairment . Cell death & disease . 2019

The detrimental effects of glucocorticoids exposure during pregnancy on offspring’s cardiac functions mediated by hypermethylation of bone morphogenetic protein-4[ . Cell death & disease . 2018

The LINK-A lncRNA interacts with PtdIns (3, 4, 5) P3 to hyperactivate AKT and confer resistance to AKT inhibitors. Lin A, et al. Nature Cell Biology, 2017 
A novel lncRNA GClnc1 promotes gastric carcinogenesis and may act as a modular scaffold of WDR5 and KAT2A complexes to specify the histone modification pattern. Sun T T, et al. Cancer discovery, 2016

Integrative Transcriptome Analyses of Metabolic Responses in Mice Define Pivotal LncRNA Metabolic Regulators.Yang L, et al.  Cell Metabolism, 2016.

Differential transcriptome expression in human nucleus accumbens as a function of loneliness. Canli T, et al. Molecular Psychiatry, 2016

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet. 2011
CRL4B Catalyzes H2AK119 Monoubiquitination and Coordinates with PRC2 to Promote Tumorigenesis. Cancer Cell. 2012

Hypoxia Inducible Factor 2 Alpha Inhibits Hepatocellular Carcinoma Growth Through the Transcription Factor Dimerization Partner 3/ E2F Transcription Factor 1–Dependent Apoptotic Pathway. HEPATOLOGY. 2013

Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription. PNAS. 2013

Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China. PNAS. 2013

The N-terminus of histone H3 is required for de novo DNA methylation in chromatin. Proc Natl Acad Sci U S A. 2009


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